News for Healthier Living
Muscle's Master Regulator Moonlights as Gene Silencer
For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. MYOD is a transcription factor that attaches to muscle stem cell DNA and reprograms the cells to build muscle.
Like Spiderman hiding in plain sight as the unassuming photojournalist Peter Parker, this activator of genes specific to muscle has been harboring a secret identity. Scientists at Sanford Burnham Prebys and their international colleagues published findings August 6, 2025, in Genes and Development demonstrating that MYOD has its own Jekyll-and-Hyde twist, turning from a gene activator to a gene silencer.
August 8, 2025
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