News for Healthier Living

New Study Shows Alzheimer's Disease Can Be Reversed in Animal Models to Achieve Full Neurological Recovery, Not Just Prevented or Slowed

Since its discovery, Alzheimer's disease has been considered irreversible. Consequently, research has focused on preventing or slowing the disease, rather than reversing it. Using different mouse models of Alzheimer's and analysis of human Alzheimer's brains, researchers showed that the brain's failure to maintain normal levels of a central cellular energy molecule, known as NAD+, is a major driver of Alzheimer's. They showed in animal models not only that preserving normal brain NAD+ balance blocks the onset of Alzheimer's, but also that restoring brain NAD+ balance in advanced stages of Alzheimer's enables the brain to reverse pathology and restore normal cognitive function. Therapies that restore brain energy balance could offer a path to recovery from Alzheimer's. These findings encourage new research into complementary approaches and clinical testing in patients.

December 23, 2025


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