News for Healthier Living
SPRED2 loss drives liver cancer stemness via p53/miR-506-3p/KLF4
Researchers have identified a new tumor-suppressive circuit that controls stem-like behavior in hepatocellular carcinoma (HCC). The work shows that Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) binds the tumor suppressor p53, enters the nucleus, and activates transcription of the microRNA miR-506-3p. In turn, miR-506-3p directly targets KLF4 messenger RNA, lowering KLF4 protein and reducing cancer stem cell (CSC) traits, including sphere formation, colony growth, invasion, and aldehyde dehydrogenase (ALDH) activity. The study defines a SPRED2/p53/miR-506-3p/KLF4 axis and suggests that restoring this pathway could help suppress HCC progression, recurrence, and treatment resistance.
October 8, 2026
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